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It is often prescribed to treat depression, obsessive-compulsive disorder, post-traumatic stress disorder, panic attacks, social anxiety disorder, and premenstrual dysphoric disorder. Tapering off Zoloft Including Lifestyle Changes and Alternative Therapies Community Q&A21 References Zoloft, or sertraline, is an antidepressant in a class known as selective serotonin reuptake inhibitors (SSRIs). There are 21 references cited in this article, which can be found at the bottom of the page. from the Temple University School of Medicine in 2007. With all the different depression and anxiety medications on the market, it can be hard to know which drug is which. Lexapro and Zoloft are two of the more commonly prescribed medications for mood disorders such as depression. These drugs are a type of antidepressant called selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing levels of serotonin, a substance in your brain that helps maintain your mood. 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