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    Viagra liver side effects


    The use of phosphodiesterase-5 (PDE5) inhibitors is not recommended in patients with preexisting cardiovascular disease for whom sexual activity is inadvisable due to the potential cardiac risk. Physicians should also consider the vasodilatory effect of these drugs and whether they may adversely affect patients with underlying cardio- and/or cerebrovascular conditions, in particular those who have suffered a myocardial infarction, stroke, or life-threatening arrhythmia within the last 6 months; those with resting hypotension (BP 170/110); and those with unstable angina associated with cardiac failure or coronary artery disease. There are no controlled clinical data on the safety or efficacy in such patients. Other adverse cardiovascular effects reported include angina pectoris, myocardial infarction, AV block, ventricular arrhythmia, tachycardia, palpitation, hypotension, postural hypotension, syncope, cerebral thrombosis, cerebrovascular hemorrhage, transient ischemic attack, cardiac arrest, heart failure, and hypertension. Many of these events occurred in patients with cardiovascular risk factors and during or shortly after sexual activity. The plasma clearance of phosphodiesterase-5 (PDE5) inhibitors may be decreased in patients with severe renal impairment, resulting in drug accumulation. Therapy with these agents should be avoided in patients with severe renal disease or on renal dialysis. buy viagra pakistan Viagra tablets contain the active ingredient sildenafil, which is a type of medicine called a phosphodiesterase type 5 inhibitor. It helps you to get and maintain an erection by helping more blood get into your penis when you are sexually aroused. An erection is produced via a complex chain of events, involving signals from the nervous system and the release of chemical messengers within the tissues of the penis. One of the messengers released when you're aroused is called cyclic GMP. Cyclic GMP relaxes and widens the blood vessels in the penis, allowing more blood to enter. Cyclic GMP is normally broken down by an enzyme in the body called phosphodiesterase type 5 (PDE5). Sildenafil works by stopping this enzyme from breaking down the cyclic GMP. This allows the blood vessels in the penis to stay dilated for longer, which improves blood flow to the penis and helps produce and maintain an erection.

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    Most of us live busy lives, and some men might find it hard to see their. It's also important to know that Viagra can cause side effects, such as. buy dapoxetine canada Common Viagra side effects of Viagra Sildenafil citrate are stuffy nose, headaches, warmth or redness in the face, neck, or chest. Less common Viagra side effects include dizziness, increased frequency of urination, indigestion, pain on urination, and stomach upset. Other adverse cardiovascular effects reported include angina pectoris, myocardial infarction, AV block. PDE5 inhibitors Includes Viagraliver disease.

    Drugs that are on the market to treat erectile dysfunction could have another use: they might be able to protect the liver from damage caused by sepsis, a systemic inflammatory response to infection, say researchers. Drugs that are on the market to treat erectile dysfunction (ED) could have another use--they might be able to protect the liver from damage caused by sepsis, a systemic inflammatory response to infection, say researchers at the University of Pittsburgh School of Medicine. They recently published their findings in Infection can lead to the release of chemicals that cause whole-body inflammation, which can cause life-threatening damage to organs including the liver and kidneys, explained senior investigator Timothy Billiar, M. D., professor and chair of surgery, Pitt School of Medicine. Sepsis is a leading cause of death in the intensive care unit. "Sepsis is a very challenging problem, so the possibility that we might be able to repurpose a drug that is in use and well understood is very exciting," Dr. Sepsis triggers production of a protein called tumor necrosis factor, or TNF, which helps fight infection but is harmful at sustained high levels. The researchers found in a mouse model of sepsis that sildenafil, more commonly known as Viagra, induced the liver to produce greater amounts of a protein called cyclic GMP, which in turn led cells to shed surface proteins called TNF receptor, reducing TNF signaling in the cells and preventing liver damage. Links to other sites are provided as a convenience to the viewer. Pfizer accepts no responsibility for the content of linked sites. This website is neither owned nor controlled by Pfizer. Pfizer does not endorse and is not responsible for the content or services of this site. Continue You are now leaving to enter a website neither owned nor operated by Pfizer. Links to all outside sites are provided as a resource to our visitors and do not imply an endorsement or recommendation of a particular physician by Pfizer, nor an endorsement of any Pfizer product by a telehealth provider or any physician. Pfizer accepts no responsibility or liability for the content or services of other websites.

    Viagra liver side effects

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  3. Sible link between sildenafil use and liver dam- age are limited. Sildenafil citrate Viagra® is a vasoactive agent. Common side effects include head- aches.

    • Sildenafil-associated hepatoxicity - European Review for Medical.
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    Sildenafil has been associated with rare instances of clinically apparent liver injury. and is available generically and under the brand name Viagra in tablets of 25. Common side effects include dizziness, headache, flushing, hypotension. prednisolone acetate generic Common side effects include headaches, heartburn, and flushed skin. Studies on the effects of viagra when used recreationally are limited, but suggest it has little effect when used by those not suffering from erectile dysfunction. Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450. Talk to your doctor about erectile dysfunction ED treatment with VIAGRA®. For others, ED symptoms can happen just once in a while. or have had stomach ulcers; have liver problems; have kidney problems or are having kidney dialysis.

     
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