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Viagra chemical structure

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    Viagra chemical structure


    Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, c GMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased c GMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH. xanax fatal dose S, was discovered through a rational drug design programme by the pharmaceutical company Pfizer. It is a potent selective inhibitor of the enzyme phosphodiesterase (PDE-5), which destroys cyclic guanosine monophosphate (c GMP), itself a dilator of blood vessels in the body. Viagra thus allows cyclic GMP to persist and this property has led to its use for the oral treatment of male erectile dysfunction (N. The structures below were modelled using a program called Chem3D from Cambridge Soft, using molecular mechanics (MM2) and quantum mechanics (AM1, PM3) methods.

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    Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile. Chemical and physical data. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in. can propranolol Three Dimensional modelled molecular structure of Sildenafil. Viagra Sildenafil Sildenafil, trade name VIAGRATM, chemical name. Order Cheap medications at the Best Prices. Buy viagra. Order viagra. Purchase viagra. Viagra Online.

    In 3D with Jsmol Viagra -- Sildenafil Citrate Sildenafil citrate, sold under the names Viagra, Revatio and under various other names, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer. Its primary competitors on the market are tadalafil (Cialis), and vardenafil (Levitra). History Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections.[1][2] Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year.[3] It soon became a great success: annual sales of Viagra in the period 1999–2001 exceeded $1 billion. The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim which Pfizer disputes.[4] Their names are on the manufacturing patent application drug, but Pfizer claims this is only for convenience. The abbreviations used are s for singlet, d for doublet, t for triplet and q for quartet. The chemical shifts are given in ppm (parts per million) and are followed by the number of Hydrogens the peaks account for: Viagra aims at inhibiting the enzyme phosphodiesterase PDE5. It must therefore have a structure that is similar in some places to the substrate. However, there are many other constraints as there are several different types of PDE enzymes which are found in different parts of the body. Of the 7 types of PDE, three selectively hydrolyse c GMP relative to c AMP. PDE5 itself can be found in several parts of the body : the lungs, platelets and various forms of smooth muscle. Selectivety was a very important factor in the research for an inhibitor of PDE5.

    Viagra chemical structure

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