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  1. sanwebm New Member

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    When you think of erectile dysfunction (ED), you probably think of Viagra. Continue reading to learn about other ED drugs, as well as some alternative methods of treating ED. That’s because Viagra was the first oral pill to treat ED. Although Viagra is considered to be the most common medication for ED, there are quite a few on the market. Viagra can be very effective in treating ED, but it’s not right for everybody. They all work by improving blood flow to the penis so that you can get and maintain an erection long enough to have sex. Because of each medication’s unique chemical makeup, you may react differently to each of them. It may take a little trial and error to determine which one works best for you. Taking oral medications generally isn’t enough to provide an erection. where can i buy augmentin online If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice.

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    Sildenafil Citrate only helps men to have erections temporarily while the drug is active. Erectile Dysfunction is a condition that affects half the population of men over 40. Since ED is not a hopeless condition, Sildenafil can still work wonders in the body to enable men to achieve erections. can i buy viagra over the counter in usa The synthesis of sildenafil citrate was first reported in the Bioorganic & Medicinal Chemistry Letters, Vol 6, pp. 1819, 1824, 1996. The reaction scheme is. How can we make viagra at home Discount generic viagra 100 mg 10 pills for 38.00 USD.

    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Sildenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.

    How to make sildenafil

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  4. Feb 5, 2003. I certainly won't be needing any of that, but it made me think, what about other drugs - such as Viagra. How hard would that be to make on your.

    • Can I make my own Viagra? - Straight Dope Message Board
    • How can we make viagra at home, how to make sildenafil at home.
    • Viagra Sildenafil Citrate Side Effects, Interactions, Warning, Dosage.

    Sep 1, 2015. As with any medication, Viagra and other erectile dysfunction. Many men make the mistake of taking Viagra, Levitra, or Spedra after a meal. amoxicillin not working for ear infection They'll ask you some questions about your general health to make sure sildenafil is safe for you to take. You can also talk to them about side effects. Alcohol Drinking more than one or two units of alcohol will make Viagra less effective. Excessive alcohol can compromise erections regardless of erectile.

     
  5. Mariya New Member

    The chemical name of duloxetine hydrochloride is (S)-( )-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride (1). There are several reports on optical resolution of racemic duloxetine and it's racemic intermediates by using resolving chiral acids such as tartaric acid, dibenzoyl-L-tartaric acid, di-p-toluoyl-L-tartaric acid, mandelic acid, camphor sulphonic acid, (S)-2-pyrrolidine-2-one-5-carboxylic-acid and (−)-2,3,4,6-di-O-isopropylidine-2-keto-L-gulonic acid. WO 2006/045255 teaches the use of D-tartaric acid to resolve racemic N, N-dimethyl-3-(1-naphthylenyloxy)-3-(2-thienyl)propanamine (5a 5b) followed by two recrystallizations of the resulting tartarate salt from tetrahydrofuran as solvent to preferentially isolate (S)—N, N-dimethyl-3-(1-naphthylenyloxy)-3-(2-thienyl)propanamine-(D)-tartarate salt in 25% yield and 99% chiral purity. The use of phase transfer catalysts render the process economically non viable since they are much costlier. Thus, the methods described in prior art for condensation of racemic hydroxy compound with 1-fluoronaphthalene that utilizes sodium hydride, alkoxide or phase transfer catalyst for large-scale reactions suffers from several drawbacks, such as: These drawbacks of the condensation reactions associated with the prior art processes are overcome by the present invention in which the condensation is achieved by using milder bases such as sodamide potassium amide and potassium bis(trimethylsilyl)amide (see scheme II). This patent although mentions that the resolution of racemic mixture 5a 5b can be carried out using resolving agent such as dibenzoyl-D-tartaric acid and dibenzoyl-L-tartaric acid (referred to as DBTA hereafter) and the like, however, it does not provide an enabling disclosure for the same. The inventors of WO 2004/056,795 have successfully replaced sodium hydride with alkali metal hydroxides, alkali metal carbonates, alkali metal bicarbonates preferably with potassium hydroxide but the condensation reaction requires to be carried out in presence of phase transfer catalyst such as crown ethers, quaternary ammonium salts, quaternary phosphonium salts to facilitate the reaction. WO 2006/126,213 describe condensation of racemic hydroxy compound with 1-fluoronaphthalene in organic polar solvent such as dimethyl sulfoxide, dimethyl formamide, dimethyl acetamide in presence of alkoxide base such as sodium methoxide, sodium ethoxide and potassium tert. As mentioned above, the alkoxides are very strong bases and hazardous which restrict their use on plant scale reactions. 5,023,269 discloses general method for preparation of (R, S)N, N-dimethyl-3-(1-naphthylenyloxy)-3-(2-thienyl)propanamine (5a 5b) that is isolated as its oxalate salt. Sodium hydride is very hazardous reagent because it is pyrophoric and reacts violently with water with evolution of hydrogen gas. The alkoxides are very strong bases and therefore are hazardous that brings limitation on their use on large scale. Most of the literature data indicate that the initial step of duloxetine synthesis is condensation of either racemic hydroxy compound i.e. N-dimethyl-3-hydroxy-3-(2-thienyl)propanamine or enantiomerically pure (S)—N. N-dimethyl-3-hydroxy-3-(2-thienyl)propanamine with 1-fluoronaphthalene by using sodium hydride as base in polar aprotic solvent. 6,541,668 describes synthesis of 3-aryloxy-3-arylpropanamines by reaction of alkoxide of 3-hydroxy-3-arylpropanamine with a halo-aromatic in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone as solvent. These pathways are illustrated in the following synthetic scheme I. Numbers of documents are cited in the patent as well as academic literature for the synthesis of duloxetine and its enantiomerically pure intermediate compounds via an optical resolution of racemic duloxetine or racemic intermediates that are formed in the synthesis of duloxetine at different steps. Duloxetine Sigma-Aldrich clomid 25 Concise Enantioselective Synthesis of Duloxetine via. US8269023B2 - Process for preparation of duloxetine.
     
  6. armen-chik Well-Known Member

    If you’re looking for a less costly Viagra, you might want to ask your doctor about sildenafil. It's the active ingredient in both branded Viagra and the drug Revatio, which is a lower dose than Viagra and approved to treat pulmonary arterial hypertension. The important difference: Generic Revatio is available for a fraction of the cost. "Generic Revatio is considerably less expensive, and it is the same drug as Viagra with the same safety and effectiveness," says Bradley Anawalt, M. D., an endocrinologist and professor of medicine at the University of Washington in Seattle who chairs the Endocrine Society's Hormone Health Network. At a lower dose, sildenafil is approved to treat pulmonary arterial hypertension—the higher dose is reserved for treating erectile dysfunction (ED). Anawalt explains that there's a chance your insurance might not cover it to treat ED. Viagra website UsaBuyPills2018 zoloft dea schedule VIAGRA® sildenafil citrate Clinical Studies - Pfizer Medical Information Where can I buy Viagra? - - LloydsPharmacy Online Doctor
     
  7. Melisa New Member

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