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    Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. By clicking Subscribe, I agree to the Terms & Conditions and Privacy Policy and understand that I may opt out of subscriptions at any time. metformin in dogs In COMBIFLAM PLUS Tablet, Caffeine belongs to the class of drugs called methylxanthines. This drug acts by blocking certain pain receptors in the brain, thereby it helps to reduce pain. Paracetamol belongs to the class of drugs called analgesics. This drug acts by blocking pain impulse generation, thereby it helps in pain reduction. If you miss a dose of COMBIFLAM PLUS Tablet, please take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. It is unsafe to use COMBIFLAM PLUS Tablet in hypertension, as it worsens the condition. It is unsafe to use COMBIFLAM PLUS Tablet with warfarin. Do not take a double dose to make up for the missed dose. It is unsafe to take COMBIFLAM PLUS Tablet in peptic ulcer condition. As these drugs interact to cause unwanted side effects.

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    Generic Combliflam is an instant relief drug that consists of a combination of paracetamol and ibuprofen. Generic Combiflam works by preventing the action of some local hormones called prostaglandins. The prostaglandins are known to produce inflammatory reaction to areas and prevent the spread of inflammation from one part of the body to other. These inflammatory reactions are prevented when drugs like ibuprofen binds with them and prevents them exerting their action. Generic Combiflam is to be taken with sufficient quantities of plain water unless otherwise indicated by the physician. Make sure to not use the drug with hot water or cold water as the temperature may hamper the structure of the drug and hinder the efficacy and outcome of the drug. You can break them into equal halves, but try your best to not crush them. The use of these tablets is not recommended for patients suffering from gastric problems, ulcer, liver and other stomach related problems. Combiflam is the combination of two active ingredients such as ibuprofen and paracetamol. Ibuprofen is a nonselective inhibitor of an enzyme called cyclooxygenase (COX), which is required for the synthesis of prostaglandins via the arachidonic acid pathway. COX is needed to convert arachidonic acid into prostaglandin H2 (PGH2) in the body. The inhibition of COX by ibuprofen therefore reduces the amount of prostaglandins produced by the body. Paracetamol selectively inhibits COX activity in the brain, which may contribute to its ability to treat fever and pain. This activity does not seem to be a direct inhibition when an active site is blocked, but it reduces COX that needs to be oxidized to function. , The combination of ibuprofen and paracetamol blocks the production of these chemicals in the body that cause pain, fever, swelling and inflammation. Consult your doctor before using this drug if: Combiflam Tablet may be unsafe during pregnancy.

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