The effects of light at wavelengths of 240–600 nm on solutions of chloroquine in isopropanol, and of light at wavelenghts of 320–600 nm on solutions of chloroquine in buffer solutions were investigated. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Hydroxychloroquine for lupus epocrates Ocular testing for plaquenil Hydroxychloroquine sulfate rheumatoid arthritis Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Hydroxychloroquine HCQ is a 4-aminoquinoline that differs from chloroquine CQ by the addition of a hydroxyl group. It was first synthesized in 1944 and initially used as an antimalarial agent. Ph. Eur. 6.2 Chloroquine Phosphate. A white or almost white, hygroscopic, crystalline powder. It exists in two forms, one melt-ing at about 195° and the other at about 218°. Freely soluble in water; very slightly soluble in alcohol and in methyl alcohol. A 10% solution in water has a pH of 3.8 to 4.3. Store in airtight con-tainers. Protect from light. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Chloroquine stability in water Hydroxychloroquine Professional Patient Advice -, Pharmacokinetics and Bioequivalence Study of. Plaquenil congestive heart failure International Journal of Pharmaceutics, 72 1991 11-18 1991 Elsevier Science Publishers B. V. 0378-5173/91/$03.50 ADONIS 0378517391002014 UP 02399 11 Photochemical stability of biologically active compounds. IV, Photochemical degradation of chloroquine Karin Nord, Jan Karlsen and Hanne Hjorth Tnesen Institute of Pharmacy, Department of. Photochemical stability of biologically active compounds. IV.. Chloroquine - DrugFuture. Chloroquine Oral Uses, Side Effects, Interactions.. Chloroquine CAS NO.54-05-7 is stability stable, but light sensitive. It is incompatible with strong oxidizing agents. It is soluble in water, insoluble in alcohol, chloroform and ether. Tonic water was never intended as a cure or preventive for malaria, but malaria is the reason the quinine is in there. Quinine has a bitter taste. To make the stuff palatable when used as an antidote for fevers, legend has it, British colonials in India mixed quinine with gin and lemon or lime. Over time they learned to love the godawful stuff. A 16.67 mg chloroquine PHOSPHATE/mL oral suspension equivalent to 10 mg chloroquine BASE/mL may be made from tablets. Crush two 500 mg chloroquine PHOSPHATE tablets equivalent to 300 mg BASE/tablet in a mortar and reduce to a fine powder. Add a small amount of sterile water for irrigation.