It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Chloroquine dosing prophylaxis Multifocal erg and plaquenil PLAQUENIL is indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults. Rheumatoid Arthritis. PLAQUENIL is indicated for the treatment of acute and chronic rheumatoid arthritis in adults. CONTRAINDICATIONS. Use of PLAQUENIL is contraindicated in patients with known hypersensitivity to 4 Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Proton pump inhibitor PPI prophylaxis is routinely—and unnecessarily—recommended for patients taking corticosteroids without concomitant NSAID use, researchers say. The prescription is not only inappropriate, based on a recent literature review showing that peptic ulcers are not a cause of concern in this scenario, but also potentially dangerous to the patient. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Taking plaquenil and ppi Hydroxychloroquine Plaquenil, Taking Plaquenil for Rheumatoid Arthritis Chloroquine cell effectPlaquenil and osteoporosisHydroxychloroquine pillCan you take hydroxychloroquine for the fluGlioma chloroquine in vivo Does Plaquenil Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in. Plaquenil Oral Interactions with Other Medication. Inappropriate prescription of PPIs in the setting of steroid use.. Protecting your eyesight when taking Plaquenil Lupus.. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Today on WebMD Medications That Make You Tired Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. People should space out doses between PPIs and H2 blockers when taking them together. Doctors may recommend taking the PPI in the morning and the H2 blocker in the afternoon or evening. People should wait four to 12 hours after taking an H2 blocker before taking their next PPI.