Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil acetaminophen interaction Plaquenil side effects skin rash pictures Plaquenil reviews rheumatoid arthritis Hydroxychloroquine sulphate indications Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. OCT scan top of normal macula compared to Plaquenil Toxicity bottom with loss of the outer retinal tissue around the macular center red boxes View more retina images at Retina Rocks, the world’s largest online multimedia retina image library and bibliography repository. In analyzing SD-OCT, it is imperative to pay special attention to the outer retina Figure 3. Thinning of the photoreceptor layer, ellipsoid layer, outer nuclear layer, and RPE can be among the earliest signs of hydroxychloroquine toxicity. 4 These changes often occur in the parafoveal area, although they can be more peripheral in Asian patients. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct image plaquenil toxicity Spotting the Telltale Signs of Plaquenil Toxicity, Plaquenil Toxicity - Bennett & Bloom Eye Centers Hydroxychloroquine patient britishPlaquenil toxicity guidelinePlaquenil copay card Plaquenil Toxicity - Bulls Eye Maculopathy 878 views 70-year-old woman with systemic Lupus erythematosus and clotting problems. She was on the Plaquenil for about eight years and then off the Plaquenil for the last eight years because she developed macular toxicity. Plaquenil Toxicity - Bulls Eye Maculopathy - Retina.. Retina Today - Imaging in Hydroxychloroquine Toxicity.. Plaquenil Toxicity - OCTMD. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. drug toxicity, hydroxychloroquine, photoreceptors. Normal Spectralis spectral domain optical coherence tomography SD OCT image with intact photoreceptor inner segment/outer segment junction. SD-OCT images demonstrated loss of photoreceptor inner segment/outer segment IS/OS junction and a downward “sink-hole” displacement of inner retinal structures in areas of hydroxychloroquine toxicity corresponding to HVF 10-2 defects and ophthalmoscopic clinical examination findings. SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution.