Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Drugs for chloroquine resistant malaria Is mefloquine a chloroquine Chloroquine prophylaxis dosage Chloroquine With primaquine. Treatment of malaria To treat Malaria we most understand 2 concept • The geographic pattern of susceptibility of P. Falciparum to antimalarial drugs. • The type of plasmodium species causing the infection. Chloroquine- sensetive areas Chloroquine -resistant areas Chloroquine. 18. Systematic review of the extent of chloroquine resistant P. vivax and the different methodologies used to quantify therapeutic efficacy Background One of the major threats to malaria control and elimination efforts is the ongoing spread and emergence of resistance towards commonly used antimalarial drugs to treat P. falciparum and P. vivax. Challenges in Molecular Medicine University of Washington Pathology/Genome Sciences May 16, 2007 Treating Malaria What Works, What Doesn t and What s New – A free PowerPoint PPT presentation displayed as a Flash slide show on - id 3c2602-NWI0Y Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine. Chloroquine resistant malaria ppt Drug Resistance in the Malaria-Endemic World, Chloroquine resistant Plasmodium vivax review Worldwide Antimalarial. Do you need a baseline eye exam before taking hydroxychloroquineNon aqueous titration of chloroquine phosphatePlaquenil et malaria There are only a few places left in the world where. chloroquine is still effective including parts of Central America and the Caribbean. CDC keeps track of all the places in the world where malaria transmission occurs and which malaria. drugs that are recommended for use in each place. Medicines for the Prevention of Malaria While Traveling.. PPT – Treating Malaria What Works, What Doesn’t and What’s New.. CDC - Malaria - Malaria Worldwide - How Can Malaria Cases.. DRUG RESISTANT MALARIA Chloroquine resistance Chloroquine is ineffective in almost all malaria endemic countries In India chloroquine resistance was first detected in 1973 in Assam. Severe in northeast and southeastern regions of India with high morbidity and mortality. Chloroquine sensitive malaria Chloroquine 10mg/kg bw stat dose followed by 10mg/kg on 2nd day f/b 5mg/kg bw on 3rd day or Chloroquine 10mg/kg bw f/b 5mg/kg at 6hr,24 hrs & 48hrs Add Primaquine 0.25-0.5mg/kg bw/ day for 14 days only if G6PD levels are normal This chloroquine level resides for about 2-3 weeks in blood, thus prevents the first Relapse of P.vivax which generally occurs at 3wks after onset of primary illness. Chloroquine has long been the drug offered to patients with unconfirmed malaria and those diagnosed with P vivax infection. Given the rise of drug resistance in many infectious agents due to poorly regulated drug use, it is no surprise that resistance has occurred in the organism that so frequently infects us.