Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Tablet, Oral, as phosphate: Generic: 250 mg [equivalent to chloroquine base 150 mg], 500 mg [equivalent to chloroquine base 300 mg] Binds to and inhibits DNA and RNA polymerase; interferes with metabolism and hemoglobin utilization by parasites; inhibits prostaglandin effects; chloroquine concentrates within parasite acid vesicles and raises internal p H resulting in inhibition of parasite growth; may involve aggregates of ferriprotoporphyrin IX acting as chloroquine receptors causing membrane damage; may also interfere with nucleoprotein synthesis Rapid and almost complete Widely in body tissues including eyes, heart, kidneys, liver, leukocytes, and lungs where retention is prolonged Partially hepatic to main metabolite, desethylchloroquine Urine (~70%; ~35% as unchanged drug); acidification of urine increases elimination; small amounts of drug may be present in urine months following discontinuation of therapy Serum: Oral: Within 1-2 hours 3 to 5 days ~55% Malaria: Treatment of uncomplicated malaria due to susceptible strains of Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, and Plasmodium falciparum; prophylaxis of malaria (in geographic areas where chloroquine resistance is not present). Chloroquine injection dosage Does hydroxychloroquine affect menstrual cycle Chloroquine Phosphate Tablets are an antimalarial and amebicidal drug. Each tablet, for oral administration, contains 250 mg chloroquine phosphate equivalent to 150 mg base or 500 mg chloroquine phosphate equivalent to 300 mg base. A metabolite of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length. Do not use for the treatment of complicated malaria (high-grade parasitemia and/or complications [eg, cerebral malaria, acute renal failure]) or for malaria prophylaxis in areas where chloroquine resistance occurs (resistance to chloroquine is widespread in P. Additional data may be necessary to further define the role of chloroquine in the treatment of this condition. Limitations of use: Chloroquine does not prevent relapses in patients with vivax or ovale malaria (not effective against exoerythrocytic forms). Extraintestinal amebiasis: Treatment of extraintestinal amebiasis. Data from a prospective, randomized, controlled, double-blind clinical trial supports the use of chloroquine in the treatment of discoid lupus erythematosus . Chloroquine phosphate 250 mg tablets Chloroquine phosphate REEF2REEF Saltwater and Reef., Chloroquine - Wikipedia Plaquenil ingredientsEr pr her breast cancer chloroquine Chloroquine Phosphate-250 mg 250mg - 10 Tablets Tablet Chloroquine drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. It is. Drug - Chloroquine Phosphate-250 mg 250mg - 10 Tablets.. Chloroquine Phosphate - WebMD. Chloroquine Phosphate Prices, Coupons & Savings Tips - GoodRx. For aquarium use only. This product is designed to be used in a bare bottom quarantine tank and it is not reef safe. Avloclor Tablets - Summary of Product Characteristics. Tablets containing 250 mg chloroquine phosphate, which is equivalent to 155 mg chloroquine base. Mean bioavailability from tablets of chloroquine phosphate is 89%. Chloroquine is widely distributed in body tissues such as the eyes, kidneys, liver, and lungs where retention is. The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 250 mg tablet of chloroquine phosphate is equivalent to 150 mg base. For malaria suppression Adult Dose 500 mg = 300 mg base on exactly the same day of each week.