Additionally, another exception occurred while executing the custom error page for the first exception. The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Plaquenil and erosive osteoarthritis Plaquenil corneal toxicity Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Doses lower than 5 mg/kg/day have low risk 1% for the first 5 years, and below 2% between 5-10 years of use. The longer you use the medication, the higher the risk of toxicity. Eye Exam and Testing for Plaquenil. For the first 5 years annual screening is appropriate. In addition to the previous discussion of a thorough complete eye exam with best corrected vision, central visual field, color vision, and dilated retinal exam, other tests include multifocal ERG, spectral domain OCT, and autofluoresence of the macula. If you stopped taking Plaquenil, how long did it take for side effects to subside? This will put you to the top of the list for more replies. Please review the following URL and make sure that it is spelled correctly. 5 years for plaquenil to leave eye The Risk of Retinal Toxicity with Plaquenil, Hydroxychloroquine And Chloroquine Screening 2016 AAO. Does hydroxychloroquine suppress the immune system Dr. Fung’s case involved a 48-year-old woman with lupus. Nine years after discontinuing medical therapy, the patient had new scotomas, difficulty reading and progression of bull’s-eye maculopathy. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Rx Side Effects New Plaquenil Guidelines and More - American.. Plaquenil Hydroxychloroquine Side Effects and Adverse.. Plaquenil Updates eyeupdate. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more likely to occur in individuals taking high doses for many years, individuals 60 years or older, or those with significant kidney disease. At the recommended dose, development of visual problems due to the medication is rare. Went back this year, and I’ve lost 40% of my peripheral vision, and am showing “quite severe” plaquenil related toxicity of the retina. Wtf. The eye doctor said it normally takes at least 10 years for people to start having problems with their eyes while on plaquenil, and when they do it comes on a lot slower than this.