Pompe glycogen storage and hydroxychloroquine

Discussion in 'Hydroxychloroquine' started by Sensus_veris, 01-Mar-2020.

  1. Pompe glycogen storage and hydroxychloroquine


    Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy.

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    Chloroquine CQ or hydroxychloroquine 4. The best charac-terized of these is the lysosomal storage disorder, Pompe disease, also known as glycogen storage disease type II. Pompe disease is caused by a mutation in the gene encoding acid a-glucosidase GAA, an enzyme that localizes to the lysosome, and hydrolyzes glycogen to glucose 5–7. Pompe disease glycogen storage disease type II a or acid maltase deficiency is a lysosomal disorder in which acid α-glucosidase GAA deficiencies lead to intralysosomal accumulations of glycogen in all tissues, most notably in skeletal muscles. Pompe disease is an inherited disorder caused by the buildup of a complex sugar called glycogen in the body's cells. The accumulation of glycogen in certain organs and tissues, especially muscles, impairs their ability to function normally. Researchers have described three types of Pompe disease, which differ in severity and the age at which they appear.

    Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease.

    Pompe glycogen storage and hydroxychloroquine

    Pearls & Oy-sters Hydroxychloroquine-induced toxic., Lysosomal storage disorders affecting the heart a review.

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  7. Pompe disease happens when your body can't make a protein that breaks down a complex sugar, called glycogen, for energy. Too much sugar builds up and damages your muscles and organs. Pompe disease causes muscle weakness and trouble breathing. It mostly affects the liver, heart, and muscles.

    • Pompe Disease Symtoms, Causes, Treatments.
    • Pompe disease - Genetics Home Reference - NIH.
    • Dietary Management of the Ketogenic Glycogen Storage..

    Pompe Disease, a glycogen storage most notably in skeletal muscle disease type II is an autosomal recessive disorder caused by deficiency of acid α glucosidase the lysosomal enzyme. It occurs due to mutation in acid α-glucosidase gene which is located on chromosome 17q25.3. Chloroquine and hydroxychloroquine, commonly used for rheumatologic conditions, are rare yet very important causes of toxic myopathy with vacuolar changes on muscle biopsy. Pompe disease, a glycogenosis due to deficiency of lysosomal acid α-glucosidase GAA, may sometimes show similar yet less marked changes on muscle histopathology. The best characterized of these is the lysosomal storage disorder, Pompe disease, also known as glycogen storage disease type II. Pompe disease is caused by a mutation in the gene encoding acid a-glucosidase GAA, an enzyme that localizes to the lysosome, and hydrolyzes glycogen to glucose –.

     
  8. chomax New Member

    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Since the pivotal trial evaluating the effect of temozolomide (TMZ), overall survival has not increased. Oncotarget Chemical modulation of autophagy as an adjunct. Free Radical Biology and Medicine The COC Protocol in Glioma - Care Oncology US
     
  9. piraniya Guest

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Leg ulcers in antiphospholipid syndrome secondary to systemic. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria
     
  10. wynn User

    Plaquenil Uses, Dosage & Side Effects - Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  11. RomanV Moderator

    Taking Plaquenil for Rheumatoid Arthritis Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. When the first biologic DMARD received FDA-approval in 1998, and as other biologics followed in subsequent years, it appeared as though Plaquenil would become less prescribed.

    Plaquenil for Psoriatic Arthritis? - Psoriasis - Inspire