Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have now come up with a potential new therapy for pancreatic cancer patients. The researchers have found that a new combination therapeutic approach can effectively fight the disease and prolong survival among patients. Natural substitute for plaquenil Chad hummel ophthalmologist plaquenil Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing. Phase I Trial of Trametinib and Hydroxychloroquine in Patients With Advanced Pancreatic Cancer THREAD Summary The purpose of this phase I trial is to study the side effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the body and cannot be removed by surgery. The results of the study were published in the latest issue of the journal The team has opened up the therapy for clinical trials at HCI as well as other centres across United States along with support from University of California, San Francisco, and Columbia University in New York. The therapy has shown promise in the laboratory set up and now is ready for use among human patients in its clinical trials. Trametinib and hydroxychloroquine Mekinist trametinib dosing, indications, interactions., Clinical Trials Using Hydroxychloroquine - National Cancer. Plaquenil cause weight gainIm chloroquineWhy is plaquenil prescribed fro sjogremsPlaquenil toxicity in macular oct layer changesCan you take phenylephrine with plaquenil The therapy would use a combination of two FDA Food and Drug Administration approved drugs that are currently being used for other types of cancer – namely trametinib and hydroxychloroquine. New therapeutic approach for patients with pancreatic cancer. Phase I Trial of Trametinib and Hydroxychloroquine in.. Trametinib and Hydroxychloroquine in Treating Patients With.. Compare Chloroquine vs Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Chloroquine rated 10.0/10 vs Hydroxychloroquine rated 6.7/10 in overall patient satisfaction. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a half-life of about 40 days and a large volume of distribution. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.