Methotrexate is one of the most commonly used drugs to treat RA. However, it can decrease the levels of an important vitamin in your body called folate. Chloroquine salt Plaquenil chronic fatigue syndrome Plaquenil huidziekten Hydroxychloroquine screening test Background 34 year old mother of 2 diagnosed in December with RA high RF and Anti-CCP. I'm on methotrexate injections just recently increased to 20 mg and plaquenil 200 mg twice a day. And folic acid. Early December I received a steroid injection to help with the pain/inflammation and improve my mobility temporarily. Folic acid may also help with many of the other common side effects from methotrexate, such as fatigue, headaches, hair loss, and oral ulcers. Ask your doctor if folic acid might help you -- don't. A weekly dose of methotrexate can cause unpleasant side effects, so Dooley recommends taking it when you have a couple of days off. For example, on Fridays, if you work during the week. “If you don’t feel 100 percent afterward, you have the weekend to get through it,” she says. It’s also important to avoid alcohol while taking methotrexate. Your doctor may suggest you take a folic acid supplement, which is a manufactured form of folate. This leads to a side effect of methotrexate called folate deficiency. Methotrexate and folic acid and plaquenil for lupus Immune & Autoimmune - Lupus methotrexate and leucovorin, Track DMARD Effects - WebMD Hydroxychloroquine cardiotoxicityScle plaquenilApo hydroxychloroquineFever from plaquenilDose of chloroquine phosphate Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Which would you pick and why? - Plaquenil or Methotrexate. Getting the most from your lupus medications Lupus.. Methotrexate - Symptoms - Life With Lupus. Low dosages of Methotrexate Rheumatrex, such as 7.5 mg given orally once per week, are extremely effective in the treatment of lupus. Methotrexate can be given orally drops mixed with water or by subcutaneous injection once a week. It is now standard practice to use folic acid to counter some of the minor side effects of Methotrexate. OBJECTIVES Methotrexate MTX has been used in several autoimmune diseases. Apart from its use in rheumatoid arthritis, MTX has been assessed in small studies in patients with vasculitis, uveitis, and inflammatory bowel disease. The aim of this study was to evaluate the efficacy of MTX in a particular group of patients with systemic lupus erythematosus SLE. PATIENTS In an open prospective. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.