These, as well as other commonly used medications, can cause various types of allergic reactions that frequently lead to hyperpigmentation (dark patches). There are four primary types of medication reactions that can lead to often troubling and disfiguring hyperpigmentation: A fixed drug eruption is a round, dark patch or eruption that results from a reaction to a drug (usually a prescription medication). Hydroxychloroquine how often eye exam Chloroquine quinine Hydroxy chloroquine Plaquenil cost in mexico Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one year after therapy discontinuation L Katie Morrison MD 1,2, James J Nordlund MD 1, Michael P Heffernan MD 1 Dermatology Online Journal 15 12 15 1. Center for Clinical Studies, Houston, Texas 2. Wright State Dermatology, Dayton, Ohio Abstract The risk of hydroxychloroquine-related retinopathy associated with skin hyperpigmentation is unknown.3 The risk of eye toxicity increases sharply toward 1% after five to seven years of hydroxychloroquine use, or a cumulative dose of 1000 g.4 Pigmentation means coloring. Skin pigmentation disorders affect the color of your skin. Your skin gets its color from a pigment called melanin. Special cells in the skin make melanin. When these cells become damaged or unhealthy, it affects melanin production. Some pigmentation disorders affect just patches of skin. Others affect your entire body. The round patch is usually fixed to one spot will appear in this same location within 24 hours of each dose taken. This type of reaction leaves a grey-blue, round patch on the skin. Hydroxychloroquine skin pigmentation Hydroxychloroquine-induced hyperpigmentation in systemic., Hydroxychloroquine-related skin discoloration CMAJ Aralen dosisBeaus lines plaquenilPlaquenil and effexorOct findings in plaquenil toxicity Skin figure 1A,B. There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accom-panied by brown coarse pigment in the dermis figure 1C,D. The pigment was negative on Perl’s stain figure 1E. This was a unique pattern of Hydroxychloroquine induced cutaneous pigmentation a unique.. Skin Pigmentation Disorders Hyperpigmentation MedlinePlus. Systemic Scleroderma Skin Involvement Hyperpigmentation and.. Hyperpigmentation of skin, mucosa, and nails can be observed in patients treated with antimalarials, including hydroxychloroquine. Elder abuse is a significant and underreported problem in seniors. Deposits in these cells can lead to cutaneous pigmentation and possibly retinal toxicity. Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. After a single dose, hydroxychloroquine is excreted mainly in the faeces, and only 20% is excreted unchanged in the urine. Brown Skin Home / Skin / Pigmentation / Drug-Induced Pigmentation. Skin Drug-Induced Pigmentation. Women with brown skin, particularly those of African and Latino descent, have a high incidence of hypertension, diabetes and heart disease and consequently take medications for those medical problems.