Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine adverse effects Buy canada hydroxychloroquine hcq Hydro chloroquine Pharmacokinetics Following a single 200 mg oral dose of Plaquenil to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended. Per the prior 2011 AAO guidelines the recommended maximum dose to minimize HCQ retinal toxicity was 6.5 mg /kg based on ideal body weight 2. The advantage of the real body weight formula is that it distributes the risk evenly on a broad range of body habitus. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. What is the maximum dose of plaquenil Taking Plaquenil for Rheumatoid Arthritis, Plaquenil hydroxychloroquine sulfate dose, indications. Volume of distribution of chloroquineEffects of hydroxychloroquine on tasteCost of aralen Mg 310 mg base to 600 mg 465 mg base PO daily, administered as a single daily dose or in 2 divided doses. Do not exceed 600 mg/day 465 mg base/day or 6.5 mg/kg/day 5 mg base/kg/day, whichever is lower. Plaquenil hydroxychloroquine sulfate dose, indications, adverse.. New Guidelines on Hydroxychloroquine Dosage - Where Are We.. Hydroxychloroquine Blood Levels in SLE Clarifying dosing.. Adults 800 mg 620 mg base followed by 400 mg 310 mg base at 6 hours, 24 hours and 48 hours after the initial dose total 2000 mg hydroxychloroquine sulfate or 1550 mg base. SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. Treatment of the acute attack— In adults, an initial dose of 800 mg = 620 mg base followed by 400 mg =310 mg base in six to eight hours and 400 mg =310 mg base on each of two consecutive days total 2 g hydroxychloroquine sulfate or 1.55 g base.