It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Hydroxychloroquine vs methotrexate Chloroquine phosphate indications Hydroxychloroquine patient teaching Can finger joints heal lupus long term usage plaquenil Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Aug 01, 2009 Everything is dark inside and outside is so bright the it is painful to open my eyes. Plaquenil toxicity is not reversible in most cases and continues to progress even after you stop taking it for several month and sometimes years because of the half life of Plaquenil One should see a retina special before taking Plaquenil in my opinion HCQ has 70–80% bioavailability after oral administration and a half-life of 50 16 days. HCQ is melanotropic and is deposited in tissue with high melanin content like skin, ciliary bodies and the retinal pigment epithelium RPE. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Retinal half life of plaquenil Hydroxychloroquine - Wikipedia, Has anyone experienced plaquenil toxicity with damage to eyes? Plaquenil sulfa allergy Oct 23, 2006 However, substitute treatments, such as glucocorticoids, also have the potential for serious systemic side effects.9,17 While the exact mechanism is unclear, glucocorticoids have been implicated in the development of central serous chorioretinopathy.17,18,19 Because hydroxychloroquine has a long half-life, the full effects may not be noticed. Does Patient with Lupus Have Plaquenil Retinopathy?. Hydroxychloroquine-related retinal toxicity Rheumatology.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. Dr. Fung’s case involved a 48-year-old woman with lupus. Nine years after discontinuing medical therapy, the patient had new scotomas, difficulty reading and progression of bull’s-eye maculopathy. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Because of the long half-life of both drugs, retinopathy can continue for over 6 months, and studies have shown ongoing changes for up to 20 years after cessation of the drugs. The goal is to detect early indications of retinal toxicity while the patient is still asymptomatic.