Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Retinal changes with plaquenil Hydroxychloroquine and chloroquine Methotrexate and plaquenil for psoriatic arthritis High risk medication plaquenil icd 10 The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. Pasadhika S, Fishman GA. Effects of chronic exposure to hydroxychloroquine or chloroquine on inner retinal structures. Eye Lond. 2010 Feb. 24 2340-6. Michaelides M, Stover NB, Francis PJ, Weleber RG. Retinal toxicity associated with hydroxychloroquine and chloroquine risk factors, screening, and progression despite cessation of therapy. Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity continuing education IUSO Online CE Ocular Side Effects of Oral Medications., Chloroquine and Hydroxychloroquine Toxicity Practice. Prednisone and plaquenil pregnancyPlaquenil surgeryChloroquine phosphate dosage in child Spotting the Telltale Signs of Plaquenil Toxicity Subtle but characteristic alterations on OCT are often your first clue. Home Current Issue Subscribe e-Newsletters Continuing Education Meetings Archives. Patient Handouts Optometric Study Center Editorial Staff Business Staff Media Kit Multimedia Web Exclusives. Spotting the Telltale Signs of Plaquenil Toxicity. Plaquenil Toxicity Screening Macula and Retina Institute c.. Multifocal ERG in Practice. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. Plaquenil is very effective for the symptoms of achiness and fatigue. However, there might be a price to pay in terms of retinal toxicity especially after taking it for as long as you have. Given that the alopecia had developed while you were on the plaquenil, it's not clear that going back on it will help that symptom much. Toxicology Continuing Education. Lifelong learning is essential for keeping on top of new developments in toxicology. Each year new exposures emerge and therapies evolve. AACT provides a wide range of live, print, and online educational opportunities and educational credit for physicians, pharmacists, nurses, and other health care providers.