I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Chloroquine and sun exposure Using chloroquine in display reef tank G6pd hydroxychloroquine After a month and a half-and being very depressed-actually ready to jump out a window--no kidding--I stopped the plaquenil--cold turkey. The bad dreams stopped, I was sleeping again, still have some stomach problems. I don't know why--I go see the RA MD tomorrow and I am sure we will discuss this. I will not take plaquenil ever again. I have psoriatic arthritus. I take an injection weekly of methotrexate. I have done this for several years now. I want to quit taking it. Can I safely quit it "cold turkey?" i.e. immediately or should I take steps of some sort? I have read about people stopping P & flaring up. Those who stopped it abruptly had real problems similar to what you are experiencing. If you really need to get off it, I would taper down slowly, very slowly. There is a similar posting on Healthunlocked, "Why oh why did u stop taking plaquenil." You may want to check it out. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Stopping plaquenil cold turkey Hydroxychloroquine MedlinePlus Drug Information, Quitting Methotrexate Cold Turkey - Arthritis Information Chloroquine retinopathy doseInteraction of plaquenil with other drugsVisual field for plaquenilGeneric plaquenil price increaseMefloquine hydrochloride chloroquine What will happen if I stop taking MTX and plaquenil cold turkey and don't get on anything else? How long before it gets out of my body? I've been on the two for over 3yrs and have high liver enzymes. I do not have a Rhuemy. Plaquenil - Complete Drug Information, Side Effects and Interactions.. Hydroxychloroquine plaquenil withdrawl? - LUPUS UK. Side effects to Stopping Plaquenil. - Sarcoidosis - Inspire. What is Plaquenil and what are its benefits for Sjögren’s patients? Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. I hate to be the bearer of bad news, but after quitting methotrexate cold turkey, I went through a period of improved quality of life 2 months, then I took a sharp decline and had the worst joint swelling I've experienced to date. Everyone is different, and since you are taking Plaquenil too, it could be less severe, only time would tell. Well, so you DON'T have the aches later. Plaquenil slows the progression of the disease. Go ahead and call the Rhuemy now, or just wait until Monday, if you have had this for a few weeks anyway. I do love a drink every now and then but will love feeling better, even if a few months from now.