Chloroquine for lung cancer

Discussion in 'Chloroquine 150 Mg' started by -==MaD==-, 26-Feb-2020.

  1. pavelgol User

    Chloroquine for lung cancer


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells Chloroquine, a drug that has historically been used to treat malaria, has recently been combined with a new drug, Tarceva, which kills lung cancer cells. Tarceva only works for some patients, and the cancer almost always becomes resistant after prolonged exposure to the drug. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Chloroquine for lung cancer

    Using Old Drugs in New Ways - Cancer Today, Repurposing Drugs 101 - Chloroquine & Lung Cancer

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  5. Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis.

    • Chloroquine Is a Zinc Ionophore - PubMed Central PMC.
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    Chloroquine CQ has been revealed to exhibit antitumor activity in several human tumors including lung cancer as mono‑ or add‑on therapy. The antitumor effect of CQ appears to depend on the tumor type, stage and genetic context. Non-small cell lung cancer NSCLC is a type of malignant cancer, and 85% of metastatic NSCLC patients have a poor prognosis. C 2-ceramide induces G2/M phase arrest and cytotoxicity in NSCLC this study, the autophagy-inducing effect of C 2-ceramide was demonstrated, and cotreatment with the autophagy inhibitor chloroquine CQ was investigated in NSCLC H460 and H1299 cells. Chloroquines are expected to have diverse effects on cancer progression. Inhibition of late autophagy can affect cell survival, as well as antigen processing and presentation in the immune system. Co.

     
  6. Ksusha Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Effects of chloroquine on viral infections an old drug. What natural resources are used to make chloroquine. What are the chemical processes used to make chloroquine.
     
  7. sernmonmers Moderator

    Drug spotlight on hydroxychloroquine Lupus Foundation of. Hydroxychloroquine belongs to the family of medicines called “antimalarials” AMs, which are also classified as disease-modifying anti-rheumatic drugs, or DMARDs. These drugs were initially used to prevent and to treat malaria but are no longer used for those purposes; more effective drugs have since been developed.

    RA and Hydroxychloroquine How Effective is it for.