Chloroquine resistance in plasmodium vivax

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  1. Violity Moderator

    Chloroquine resistance in plasmodium vivax


    ‚ÄúPresumptive treatment‚ÄĚ without the benefit of laboratory confirmation should be reserved for extreme circumstances (strong clinical suspicion or severe disease in a setting where prompt laboratory diagnosis is not available). Once the diagnosis of malaria has been made, appropriate antimalarial treatment must be initiated immediately.

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    Sep 15, 2001 The tremendous success of chloroquine and its heavy use through the decades eventually led to chloroquine resistance in Plasmodium falciparum and Plasmodium vivax the 2 parasite species responsible for most human malaria cases. P. vivax resistance to chloroquine has also now been identified in Southeast Asia, Ethiopia, and Madagascar. Isolated reports have suggested chloroquine-resistance P. vivax in other countries and regions, but further evaluation is needed. Vivax malaria parasites, particularly from Oceania. Chloroquine remains the treatment of choice for vivax malaria, except in Indonesia's Irian Jaya Western New Guinea region and the geographically contiguous Papua New Guinea, where chloroquine resistance is common up to 20% resistance. Chloroquine resistance is an increasing problem in other parts of the world, such as Korea and India.

    The clinical status of the patient: Patients diagnosed with malaria are generally categorized as having either uncomplicated or severe malaria. Treatment should be guided by three main factors: infections, the urgent initiation of appropriate therapy is especially critical.

    Chloroquine resistance in plasmodium vivax

    Plasmodium vivax Drug Resistance Genes. - PubMed Central PMC, Drug Resistance in the Malaria-Endemic World - CDC

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  7. Although Plasmodium falciparum often takes the spotlight, given its more severe course. Chloroquine has long been the drug offered to patients with unconfirmed malaria and those diagnosed with P vivax infection. Given the rise of drug resistance in many infectious agents due to poorly regulated drug use, it is no surprise that resistance has occurred in the organism that so frequently infects us.

    • Chloroquine-resistant Plasmodium vivax in Pakistan an..
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    Malaria. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations. INTRODUCTION WIDESPREAD resistance of malaria parasites to chloroquine has, so far, been restricted to Plasmodium falciparum. Chloroquine has remained the drug of choice for the prophylaxis and treatment of P vivax. We now report vivax malaria in 2 soldiers who were taking weekly chloroquine and pyrimethamine/dapsone 'Maloprim' prophylaxis. Emerging resistance to chloroquine CQ by Plasmodium vivax threatens the health of the hundreds of millions of people routinely exposed to the risk of infection with this organism. CQ has been the.

     
  8. letyn Moderator

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  9. Sish Well-Known Member

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  10. Pumpa Guest

    Simplified lentivirus vector production in protein-free. Chloroquine is commonly used for the production of lentiviral vectors Federico, 2003, Reiser et al. 1996, Salmon and Trono, 2006. In the work described here, however, chloroquine addition resulted in reduced titers when the PEI-mediated transfections were performed in DMEM medium with or without serum present Fig. 2.

    Addgene Lentivirus Production Protocol