Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine drug interactions Symptoms of hydroxychloroquine Taking hydroxychloroquine for ra Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. A case of hydroxychloroquine-induced agranulocytosis in a patient with discoid lupus erythematosus is reported. The patient had previously received chloroquine therapy for several months. Leukopenia preceded the appearance of agranulocytosis, and persisted for six weeks following clinical recovery. JAMA Network Open is now accepting submissions. This article is a review of different management strategies for the hematological manifestations of systemic lupus erythematosus SLE, the strategies include immunosuppressive drugs, some noval therapies and B-cell depletion for refractory thrombocytopenia in patients with SLE and in antiphospholipid antibody syndrome associated with SLE. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Neutropenia hydroxychloroquine Common and Rare Side Effects for, Hydroxychloroquine-Induced Agranulocytosis JAMA. Hydroxychloroquine is it smokableChloroquine lymeHydroxychloroquine sarcoidosis dosageTeva-chloroquine phosphate Neutropenia in Felty's syndrome successfully treated with hydroxychloroquine. Mahévas M1, Audia S, De Lastours V, Michel M, Bonotte B, Godeau B. Neutropenia in Felty's syndrome successfully. Hematological Disorders in Patients with Systemic. Hematological Disorders in Patients with Systemic Lupus.. A case of hydroxychloroquine-induced agranulocytosis in a patient with discoid lupus erythematosus is reported. The patient had previously received chloroquine therapy for several months. Leukopenia preceded the appearance of agranulocytosis, and persisted for six weeks following clinical recovery. Plaquenil is not effective against chloroquine or hydroxychloroquine-resistant strains of Plasmodium species see CLINICAL PHARMACOLOGY – Microbiology. Plaquenil is not recommended for the treatment of malaria acquired in geographic areas where chloroquine resistance occurs or when the Plasmodium species has not been identified. Hydroxychloroquine Plaquenil may be helpful for skin lesions and elevated blood-calcium levels. Tumor necrosis factor-alpha TNF-alpha inhibitors. These medications are commonly used to treat the inflammation associated with rheumatoid arthritis. They can also be helpful in treating sarcoidosis that hasn't responded to other treatments.