Chloroquine elimination route

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  1. allprikol Guest

    Chloroquine elimination route

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Route of Elimination Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Half Life 1-2 months Uses/Sources For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis A308.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine elimination route

    Chloroquine Indications, Side Effects, Warnings -, Chloroquine Oral Uses, Side Effects, Interactions.

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  3. Chloroquine is detectable in the urine for up to a year after drug administration. 94 Urinary excretion is the main route of elimination for both chloroquine and desethylchloroquine.

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    Dec 03, 2019 BACKGROUND Anti-malarial resistance is, and continues to be a significant challenge in the fight against malaria and a threat to achieving malaria elimination. In Zambia, chloroquine CQ, a safe, affordable and well-tolerated drug, was removed from use in 2003 due to high levels of resistance evidenced with treatment failure. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

  4. Mickey Well-Known Member

    Atovaquone/Proguanil (Malarone) Adults: 1 adult tablet daily. Malarone Atovaquone and Proguanil Hcl Uses, Dosage, Side. Chloroquine and/or Proguanil - Fit for Travel Atovaquone-Proguanil versus Chloroquine-Proguanil for Malaria.
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    Managing Arthritis in Lupus SLE Workshop Patient Education As noted, some specific types of arthritis are lupus arthritis, rheumatoid arthritis RA, and osteoarthritis. Inflammatory arthritis, such as lupus arthritis or RA, involves soft and spongy swelling of the joint, tenderness and stiffness.

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