Hydroxychloroquine induced pigmentation

Discussion in 'Canadian Pharmacy Drugs Online' started by Oleg495, 27-Feb-2020.

  1. Dominator2007 XenForo Moderator

    Hydroxychloroquine induced pigmentation


    In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent.

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    The incidence of hydroxychloroquine-related hyperpigmentation in patients with systemic lupus erythematosus is about 7%, but unlike hydroxychloroquine-related retinopathy, there is no clear association with cumulative dose or duration of use.1 Roughly half of cases occur in the first five years of treatment. An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. The imputability of hydroxychloroquine in the genesis of this discoloration is difficult to establish. Our study supports the hypothesis that ecchymosis, platelet antiaggregants and oral anticoagulants may be the main predisposing factors to hydroxychloroquine-induced pigmentation.

    Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended.

    Hydroxychloroquine induced pigmentation

    Drug-associated hyperpigmentation of the oral mucosa report., Hydroxychloroquine induced cutaneous pigmentation a unique.

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  3. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes.

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    We report two cases of hydroxychloroquineinduced hyperpigmentation presenting in a 50‐year‐old Caucasian female case 1 and a 78‐year‐old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4–5 years. Deposits in these cells can lead to cutaneous pigmentation and possibly retinal toxicity. Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. After a single dose, hydroxychloroquine is excreted mainly in the faeces, and only 20% is excreted unchanged in the urine. Sep 13, 2019 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some.

     
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    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. COVID-19 Prophylaxis in Healthcare workers. - Health 2019 Autophagy Inhibitors - Autophagy Sigma-Aldrich Chloroquine Indications, Side Effects, Warnings -
     
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    Plaquenil/Hydroxychloroquine - which eye tests do. - LUPUS UK Well, that nov post here recommended a visual field test every 6 months, and a computerised 3d retina scan every year - She said she had been on plaquenil for 12 years, regularly having these tests inc I guess doing her amsler grids and she felt they were really important, but so far she had no eye problems.

    Field vision test failed - Things You Didn’t Know