Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil tablet doses Plaquenil and benadryl Advantages of chloroquine Plaquinil hydroxychloroquine Very rarely, Stevens-Johnson syndrome/toxic epidermal necrolysis can occur. Very rarely, the skin and mucosa can change to a black-blue colour in a process called dyschromia. Hydroxychloroquine can also exacerbate psoriasis. In patients with glucose-6-phosphate deficiency, hemolysis can occur. New findings from a study published in the American Journal of Medicine may help clinicians identify high-risk drugs and high-risk patients linked to the development of Stevens-Johnson syndrome SJS/toxic epidermal necrolysis TEN in order to reduce its incidence. Mortality rates. Stevens-Johnson syndrome erythema multiforme is an acute inflammatory polymorphic disease affecting skin and mucous membranes. All ages may be affected, and the incidence is equal in both sexes. This is a severe disease with a 5%–15% mortality rate. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil steven johnson syndrome Plaquenil Side Effects Common, Severe, Long Term -, Which Drugs Are Most Associated With Stevens-Johnson Syndrome. How does hydroxychloroquine work for arthritis Download Citation On May 1, 2002, M J Leckie and others published Stevens-Johnson syndrome in association with hydroxychloroquine treatment for rheumatoid arthritis 5 Find, read and cite all. Stevens-Johnson syndrome in association with.. Stevens-Johnson Syndrome. Stevens-Johnson syndrome/toxic epidermal necrolysis Genetic.. Stevens–Johnson syndrome SJS is a type of severe skin reaction. Together with toxic epidermal necrolysis TEN and Stevens–Johnson/toxic epidermal necrolysis SJS/TEN, it forms a spectrum of disease, with SJS being less severe. Erythema multiforme EM is generally considered a separate condition. Sir, Hydroxychloroquine is widely used in the treatment of rheumatoid arthritis and systemic lupus erythematosus, with very few reported side‐effects. We report the case of a 65‐yr‐old woman who developed Stevens–Johnson syndrome 2 weeks after commencing treatment with hydroxychloroquine. Stevens-Johnson syndrome SJS and toxic epidermal necrolysis TEN are similar conditions characterized by intraepidermal cell death leading to diffuse vesicobullous eruptions. The differentiating criteria for SJS and TEN is the extent of skin detachment; SJS is defined as 10% total body surface area, SJS-TEN overlap as 10-30%, and TEN as 30%.