I've been taking it for about 6 months now, and I can't tell that it's done a thing. I think I may be overmedicated and was thinking about dropping the plaquenil if there was no benefit to it. Thanks, Elcamino Hi Elcamino, I have been taking Plaquenil (400 mg per day) for about 2 years now due to lupus flare. Plaquenil flu shot Hydroxychloroquine anti inflammatory action Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Damage to the retina, the light sensitive portion of the inner eye, can occur with long-term use of Plaquenil or chloroquine Aralen. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Actually I started on 200 mg per day and about 2 months before tapering off pred, he upped me to 400 mg per day of plaquenil to give it plenty of time to kick in. When i first started it, I was also started on prednisone to get my inflammation under control. How long does plaquenil take to work for ra Lupus Medicines Hydroxychloroquine - Brigham and Women's., Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Hydroxychloroquine plaquenil eksisozlukChloroquine tablet in pregnancyMalaria chloroquine resistant areas Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. I have had RA for 10 years and have been on Plaquenil pretty much the whole time. Methotrexate did not work for me and made me very nauseous. I also take 5-10 mg prednisone and an injection of Humira every week. I have had no side effects from the Plaquenil. Prednisone is a mean drug however, I can tell you this as a nurse too but I have to. Donald E. Thomas Jr. MD, FACR, FACP, a practicing rheumatologist in Greenbelt, Md. and author of The Lupus Encyclopedia, regularly prescribes Plaquenil to his lupus patients. “We know that people with lupus who take their Plaquenil regularly are much more likely to live a long, normal life compared with those who don’t,” he says. Rated Hydroxychloroquine for Rheumatoid Arthritis Report Plaquenil was a miracle drug for me. It began to work in 3 weeks and within 6 months my inflammation had gone from over 40 to 5.5.