Why chloroquine has high volume of distribution

Discussion in 'Canadian Pharcharmy' started by kitoda, 09-Mar-2020.

  1. NatL XenForo Moderator

    Why chloroquine has high volume of distribution


    In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment. Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula.

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    When you have a low volume of distribution, there is a good deal of drug in the PLASMA. When you have a high volume of distribution, there is a good deal of drug in the ________. When you have a high volume of distribution, there is a good deal of drug in the EXTRAVASCULAR SPACE. Sep 30, 2014 Drugs which bind selectively to Extravascular Tissues e.g. Chloroquine have Apparent volume of distribution larger than their Real volume of distribution. The Vd of such drugs is always greater than 42 liters. Volume of distribution, elimination half-life and clearance were not different for the three regimens, ranging from 250-302 l kg-1, 374-479 h and 0.44-0.58 l h-1 kg-1 respectively. After the first week of all dosage regimens, peak and trough concentrations of chloroquine were above 16 micrograms l-1, sufficiently suppressive for chloroquine-sensitive P. falciparum strains.

    As body composition changes with age, V But this is generally not what happens. Is not a physiologic value; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. The unit for Volume of Distribution is typically reported in liters.

    Why chloroquine has high volume of distribution

    Volume of distribution Deranged Physiology, Drug distribution & clearance - SlideShare

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  5. The effect of chloroquine, paracetamol and Promethazine on the pharmacokinetic profile of chlorpropamide was investigated in human subjects. The batches of chlorpropamide, chloroquine, paracetamol and Promethazine used were subjected to quality control studies using official methods.

    • THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE..
    • The pharmacokinetics of three multiple dose regimens of..
    • Pharmacokinetics of Quinine, Chloroquine and Amodiaquine SpringerLink.

    Chloroquine was given in 300 mg single doses as an i.v. infusion, an oral solution and as tablets at intervals of at least 56 days to 11 healthy volunteers. Concentrations of chloroquine and its metabolite desethylchloroquine were measured in plasma, erythrocytes and urine using h.p.l.c. 2 Chloroquine was detectable in all plasma samples up. Conversely, it may be decreased in dehydration. Acetylsalicylic acid has a low volume of distribution and is basically distributed in blood, whereas digoxin has a high volume of distribution and is distributed into intravascular space as well as fat and muscle. Hemodialysis removes only the toxins in the intravascular space. The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data concentrations being 5 to 10 times higher. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver.

     
  6. Honey User

    Applies to chloroquine: oral tablet Along with its needed effects, chloroquine may cause some unwanted effects. Chloroquine phosphate C18H32ClN3O8P2 - PubChem Chloroquine Mechanism of drug action and resistance in. What is Chloroquine Phosphate? - GoodRx
     
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