I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Plaquenil for scalp Chloroquine autophagy Jessie, plaquenil can take up to 6 months to take effect. I was told to not not try to discontinue any of my lupus meds while my medical condition was unstable. At the time, I had a sinus infection. Jessie, 3 years ago, my doctor discontinued my plaquenil ie. hydroxychloroquen and substituted it for an older anti-malerial drug named "chloroquin". Use this medication regularly in order to get the most benefit from it. If you are taking it on a daily schedule, take it at the same time each day. Take this medication exactly as prescribed. The upside of prednisone is that it has the ability to control these flares by quickly alleviating the inflammation until other disease-modifying anti-rheumatic drugs DMARDs can take effect. While DMARDs like Plaquenil hydroxychloroquine and Arava leflunomide are more targeted in the control of the immune system, they are slower acting. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. What time should i take my prednisone and my plaquenil Prednisone MedlinePlus Drug Information, Plaquenil Oral Uses, Side Effects, Interactions. Hydroxychloroquine oral ulcers The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. Taking Plaquenil for Rheumatoid Arthritis. Benefits and Risks of Prednisone - Verywell Health. Prednisone and plaquenil -. Re best time to take plaquenil. You take plaquenil twice a day, approximately 12 hours apart. The most common side effect is mild nausea and occasional stomach cramps. You can take it with food if it upsets your stomach. You should also have a complete eye exam before starting this medication and then every 6 months. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Take this drug at the times recommended by. Compare Plaquenil vs Prednisone head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Plaquenil rated 6.8/10 vs Prednisone rated 7.7/10 in overall patient satisfaction.