As an antimalarial drug, hydroxychloroquine has been shown to accumulate in malaria parasite lysosomes, increasing the p H. This activity interferes with the capacity of the parasite to hemoglobin proteolysis, stopping ordinary development and parasite replication. Order aralen prescribing Plaquenil and diiclofenac Nov 09, 2018 Some antacids can make it harder for your body to absorb hydroxychloroquine. Hydroxychloroquine can cause serious liver or heart problems, especially if you use certain medicines at the same time. Plaquenil isn't known for causing insomnia. It is also a drug that stays in your system for a long time and takes a long time getting IN to your system. It takes 3-5 months to work and just as long to get out of your system. When you started the Plaquenil, how long did it take until you started having insomnia? Sleeping can be deceptive. Feb 14, 2011 I personally went off the Remicade after developing drug induced lupus. They say it will resolve over the next 3 to 10 months. The pain can be unbearable and I started the plaquenil 2 weeks ago. I am hoping it will help. I found a good rheumatologist who pinpointed the only cause to be the Remicade. It is believed that hydroxychloroquine acts as a mild immunosuppressant, inhibiting rheumatoid factor production and acute phase reactants. As a disease-modifying anti-rheumatic drug (DMARD), the exact hydroxychloroquine mechanism of action is yet unknown. Can hydroxychloroquine cause insomnia Hydroxychloroquine Sulfate Insomnia Reports - DrugInformer, Insomnia because of plaquenil DailyStrength Chloroquine proguanil side effectsExpired chloroquine Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil - Lupus. Did Hydrochlorothiazide Lead to Dangerously Low Sodium? The.. Can hydroxychloroquine cause liver damage? Elevated liver enzymes are a common problem in some patients being treated with hydroxychloroquine, such as patients with lupus. However, as a general rule, hydroxychloroquine is not associated with an elevation in liver enzymes when used to treat autoimmune and rheumatologic diseases. If you have psoriasis, chloroquine Aralen and hydroxychloroquine Plaquenil can cause problems. Other Medicines That Might Trigger a Flare. A few other drugs to discuss with your doctor include Does plaquenil cause insomnia? I've been taking it for weeks, I take one in the morning, one in the evening. I have not slept for 3 days straight. I thought my ambien wasn't working anymore, but I took 2 last night plus a tylenol PM, and not a wink of sleep.