Pharmacological treatment with chloroquine inhibits autophagy in vivo

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  1. googlebot Well-Known Member

    Pharmacological treatment with chloroquine inhibits autophagy in vivo


    Several cancer treatments stimulate the autophagic process and when autophagy is inhibited, cancer cells show an enhanced response to multiple treatments. These findings have nourished the theory that autophagy provides cancer cells with a survival advantage during stressful conditions, including exposure to therapeutics.

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    The inhibition of hypoxia-induced autophagy by hydroxychloroquine promoted tumor regression in an in vivo subcutaneous B16 melanoma mouse model. Chloroquine treatment combined with calorie restriction inhibited melanoma tumor growth in a subcutaneous mouse model of B16 melanoma cells. In the present study, we evaluated the effects of treatment with chloroquine alone, chloroquine + MK2206 or chloroquine + MK2206 + U0126 on cell growth and regrowth of endometriotic stromal cells in vitro. Interestingly, we found no significant difference between U0126 30 μM + MK2206 9 μM + chloroquine 50 μM and MK2206 9 μM + chloroquine 50 μM on either inhibition of cell growth or regrowth after drug discontinuation in DES cells. Chloroquine is a lysosomal inhibitor and has been shown to reverse autophagy by accumulating in lysosomes, disturbing the vacuolar H+ ATPase responsible for lysosomal acidification and blocking autophagy.

    In this review we examine two approaches to modulate autophagy as complementary cancer treatment: inhibition and induction. Therefore, interference with the autophagic response can potentially enhance the efficacy of cancer therapy.

    Pharmacological treatment with chloroquine inhibits autophagy in vivo

    Rapamycin and Chloroquine The In Vitro and In Vivo., In vitro and in vivo effects of MK2206 and chloroquine.

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  5. Autophagy has been identified as a cellular process of bulk degradation of cytoplasmic components and its persistent activation is critically involved in the renal damage induced by ureteral obstruction. However, the role and underlying mechanisms of autophagy in hyperuricemic nephropathy HN remain unknown. In the present study, we observed that inhibition of autophagy by 3-methyladenine 3.

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    Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation. 1. Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compounds that inhibit autophagy by targeting the lysosomes but through distinct mechanisms. The ratio of LC3-II to LC3-I was also upregulated by RS9 treatment at both 6 and 24 h after NaIO 3 treatment. Chloroquine co-treatment further upregulated the levels of these proteins Fig. 4 A, C. Notably, the autophagy substrate p62/SQSTM1 was transiently upregulated by RS9 treatment only at 6 h after NaIO 3 treatment Fig. 4 A, D.

     
  6. asus08 XenForo Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine - Wikipedia Generic Plaquenil Availability - PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION
     
  7. Roman XenForo Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Hydroxychloroquine Uses, Dosage & Side Effects - Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  8. Nickf Well-Known Member

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

    Retinal toxicity associated with chronic exposure to.
     
  9. DmitryB Well-Known Member

    Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums For months now my skin has been thickening I have now reached the point where I feel as though my arms are going to split like a sausage and been extremely inflamed and painful. A month ago I started on Plaquenil and prednisolone. It has helped a bit with the inflammation but on reading various.

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