Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Spell plaquenil Hydroxychloroquine 200 mg twice a day How good is Hydroxychloroquine, and any side effe. - LUPUS UK. LUPUS UK. 25,607 members • 21,035. Extensive muscle wasting which eventually resulted in a weight loss of about 40% and three near death experiences in approx. 6 years. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare. I have been on plaquenil for many a year, and it has not affected my weight at all. If you go to or rxlist.com, neither of them list weight gain as a side effect, while they both list "nausea, vomiting, stomach pain; loss of appetite, weight loss" as side effects. Plaquenil caused a loss of appitite and weight loss for me. Both times I started taking it, the first time it was so serious I had to stop taking it. Started again several years later when I flared again and had loss of appitite and weight loss but a bit more moderate. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Hydroxychloroquine and weightloss Plaquenil Side Effects Common, Severe, Long Term -, Weight gain while on Plaquenil? lupus Canyou take benadryl and plaquenil togetherIs plaquenil a anti-inflammatoryPlaquenil drug monitoringMosquitos and plaquenilSynthesis procedure of chloroquine I saw the GI doctor today I am SO TIRED of seeing doctors and after our brief meeting, he has me scheduled for a colonoscopy and upper GI scope/biopsy!I am very underweight and do have chronic diarrhea, but gosh, this seems invasive as a first step in trying to figure out anyone had chronic diarrhea/weight loss from Plaquenil? Plaquenil, diarrhea and weight loss?. Plaquenil & Weight Gain/Loss. Hydroxychloroquine Reviews Everyday Health. Does anyone know if hydroxychloroquine and methotrexate can cause weight loss. I took my 3rd dose of mtx this week as well as daily hydroxychloroquine and weekly folic acid. In 3 weeks I have lost just over half a stone. Week 1 I was very nauseous, week 2 improved and this week, I haven't thought about it. Hydroxychloroquine HCQ is a disease-modifying anti-rheumatic drug DMARD typically used for the treatment of various rheumatic and dermatologic diseases. Three studies of HCQ in OA, including one abstract and one letter, are available and use a wide variety of outcome measures in small patient populations. Common hydroxychloroquine side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss.