Treatment of porphyria cutanea tarda with chloroquine

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  1. brianka Guest

    Treatment of porphyria cutanea tarda with chloroquine


    Porphyria Cutanea Tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. PCT is essentially an acquired disease, but some individuals have a genetic (autosomal dominant) deficiency of UROD that contributes to development of PCT.

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    Porphyria cutanea tarda PCT is common in Ethiopia and invariably affects the liver. Treatment by abstension from alcohol and avoidance of direct sunlight often failed to achieve lasting improvement. The frequency of porphyria cutanea tarda PCT has been increasing greatly and its incidence at present in our country can be estimated to one case in 2000–5000 inhabitants. A striking fact is an apparent shift in the incidence of the disease to younger age groups. Kordac V, Semradova M. Treatment of porphyria cutanea tarda with chloroquine. Br J Dermatol. 1974 Jan. 90195-100. Battle AM, Stella AM, De Kaminsky AR, Kaminsky C, Mariano HG. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine.

    Most individuals with the inherited enzyme deficiency remain latent and never have symptoms. These individuals are referred to as having "familial PCT".

    Treatment of porphyria cutanea tarda with chloroquine

    Porphyria Cutanea Tarda Pictures, Treatment, and More, Chloroquine in the Treatment of Porphyria Cutanea Tarda.

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  5. If you have cutaneous porphyria, your treatment will depend on the specific type of the disease you have and how severe your symptoms are. If you have porphyria cutanea tarda, your treatment might include Regular removal of your blood to lower the amount of iron in your liver. This is called phlebotomy.

    • Porphyria Types, Symptoms, Causes, and Treatment.
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    • Porphyria Cutanea Tarda - Pictures, Diagnosis, Causes, Treatment.

    Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Porphyria cutanea tarda, the most common type of porphyria worldwide, is caused by a deficiency of uroporphyrinogen decarboxylase, a crucial enzyme in heme biosynthesis, which results in an accumulation of photosensitive byproducts, such as uroporphyrinogen, which leads to the fragility and blistering of sun-exposed skin. Aug 16, 2017 Treatment of porphyria cutanea tarda can include Regular blood removal phlebotomies to reduce the amount of iron in the liver. Low doses of the antimalarial drug chloroquine or hydroxychloroquine. Avoidance of triggers. Treatment of any underlying condition such as HIV or hepatitis C.

     
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    Drug Safety in Pregnant & Nursing Women. Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to

    Treatment of SLE in pregnancy and use of Chloroquine The BMJ