There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by incidence or effect, said Frederick W. “Rick” Fraunfelder, MD, director of the Registry and associate professor of ophthalmology at Oregon Health & Science University in Portland. Chloroquine endosome Can plaquenil cause low platelets With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Multifocal ERG ring ratios provide a clearly defined, quantitative measure for early detection of functional defects in hydroxychloroquine toxicity and other disorders characterized by pericentral lesions. Multifocal electroretinography mfERG is highly sensitive for detecting hydroxychloroquine retinal toxicity. Ring 2 P1 amplitude is the most sensitive mfERG parameter to detect hydroxychloroquine retinal toxicity. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible. “Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. Multifocal erg and plaquenil Advanced Multifocal ERG mfERG Diopsys, Detection of Early Hydroxychloroquine Retinal Toxicity. Hydroxychloroquine gastrointestinal bloatingHydroxychloroquine sulfate pharmacological classChloroquine in hepatic amoebiasisPlaquenil heart side effectsWho can prescribe plaquenil H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Retinal Physician - Hydroxychloroquine Maculopathy An.. The Diagnostic Utility of Multifocal Electroretinography.. Hydroxychloroquine And Chloroquine Screening 2016 AAO.. Rx Side Effects New Plaquenil Guidelines and More. Written By By Miriam Karmel, Contributing Writer. Plaquenil. 1. Dr. Marmor said, “We also recommend use of objective tests such as spectral domain OCT, multifocal ERG and fundus autofluorescence.” He added that older time domain OCT units lack enough sensitivity for Plaquenil. We have found recordable, though attenuated, multifocal ERG responses in patients with RP. The multifocal ERG is an objective method for following patients with extinguished full-field ERG See Figure 4. For example, the patient presented here has an extinguished ERG response, but a recordable and replicable mfERG. The abnormalities on multifocal ERG corresponded with the patients’ subjective descriptions and the visual field depiction of their pericentral scotomas. All affected patients had been taking hydroxychloroquine for at least 7 years. One patient with generalized depression on multifocal ERG had possible hydroxychloroquine retinopathy.