The revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI) can be used to assess disease activity and damage. Acute cutaneous LE affects at least 50% of patients with systemic lupus erythematosus (SLE). Specific features of acute cutaneous LE may include: See more images of systemic lupus erythematosus. Symptoms of eye problems from plaquenil Plaquenil causes leg weakness in psoriatic arthritis Subacute cutaneous lupus erythematosus SCLE is a clinically distinct disease that is associated with systemic lupus erythematosus in 50% of patients, and can be associated with Sjögren’s syndrome and patients with a deficiency in the second and fourth components of complement. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. One-third of the cases are due to previous drug exposure. About 15% of patients with cutaneous LE have subacute cutaneous LE. Plaquenil for cutaneous lupus Cutaneous Lupus Erythematosus Diagnosis and treatment, Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center Novo chloroquine 250 mgPlaquenil and prednisone combinationPlaquenil sjogren's pregnancy Cutaneous lupus erythematosus CLE is the second most common presenting symptom of autoimmune lupus erythematosus LE. Lesions precede the onset of systemic symptoms in 25 percent of patients, many of whom present to dermatologists for their initial evaluation.1 Prompt diagnosis of CLE requires a thorough understanding of the cutaneous manifestations and clinical spectrum of lupus. Treatment of Cutaneous Lupus Erythematosus. Plaquenil Uses, Dosage & Side Effects -. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.