Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Apo hydroxychloroquine side effects Prednisone for plaquenil Retinal thickness changes plaquenil toxicity Hydroxychloroquine human antihimeric antibodies If you're on steroids that can be whats causing you to gain weight. I can't offer any advice on losing the weight if you come off the Plaquenil. Like Joy said, Plaquenil is the first medication they use in treating lupus. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Yes, Plaquenil causes both weight loss and loss of appetite. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can you gain weight on plaquenil Hydroxychloroquine Side Effects Common, Severe, Long Term., Plaquenil - Uses, Side Effects, Interactions - Cost of plaquenil in irelandPlaquenil pregnancy safety Doctors give unbiased, trusted information on whether Plaquenil can cause or treat Weight Gain Dr. Valdez on hydroxychloroquine and weight gain Depression can cause weight gain and loss, but alopecia not a common sign of depression. Hydroxychloroquine and weight gain - Answers on HealthTap. Plaquenil and loss of appetite - Lupus - MedHelp. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil is the newest & safest in the class. The drug helps with skin rashes, hair loss, mouth ulcers, joint pain & swelling, fatigue, etc. It takes perhaps 3-4 months to build up & reach full effect. GOOD NEWS hair loss & weight gain are NOT associated with Plaquenil. Weight increased is found among people who take Hydroxychloroquine sulfate, especially for people who are female, 60+ old, have been taking the drug for 10+ years, also take medication Enbrel, and have High blood pressure. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA reports. The results are. Hydroxychloroquine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works.