One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Information on the medication plaquenil Plaquenil vs generic Will aches come back after stopping plaquenil American Academy of Ophthalmology AAO 2016 guidelines recommend to use HCQ at dosages ≤5 mg/kg real body weight to minimize toxicity 1. Important risk factors for retinal toxicity are daily and cumulative The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. The 2011 AAO guidelines recommended dosing hydroxychloroquine based on ideal body weight – what a patient should weigh for their height. This was supposed to ensure that people who were very short or overweight got the right amount of drug. The proposed daily dose was 6.5 mg per kg of ideal body weight. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Aao plaquenil dosing Drug spotlight on hydroxychloroquine Lupus Foundation of., Despite Plaquenil dosing recommendations, retinal toxicity. Glioma chloroquine in vivoSam's club pharmacy hydroxychloroquineHow does plaquenil affect eyesPlaquenil back injuryNaprosen and plaquenil CONCLUSIONS Twenty-seven percent of cases of hydroxychloroquine retinopathy in obese women had ostensibly safe dosing based on 2016 AAO guidelines. Overdosing of obese women by 2016 AAO guidelines is not rare. Daily dosing based on the older 6.5-mg/kg ideal weight threshold is safer in women with a body mass index of 30 kg/m2 or more. The 2016 American Academy of Ophthalmology.. Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at.. Hydroxychloroquine Professional Patient Advice -. Differential diagnosis – juxtafoveal telangiectasia – FFA to rule out In a confirmed case of tamoxifen toxicity with visual complaints, the drug must be stopped. Since maculopathy is rare, routine screening is not needed with current low dose therapy 10-20mg/day. Summary of dosing guidelines. The new recommended daily dose of HCQ is less than 5 mg/kg of real weight, which has been shown to correlate better with risk than ideal weight. There is no similar demographic data for CQ, but older literature suggests less than 2.3 mg/kg real weight. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs. There was a dose response, such that those receiving doses greater that 5 mg / kg had the greatest risk of retinal toxicity.