Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hydroxychloroquine with all of your drugs and health problems. Plaquenil and chronic fatigue Hydroxychloroquine and epsom salt bath Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have had any eye changes or changes in eyesight due to hydroxychloroquine or drugs like this one. If you have psoriasis. AGEP should be distinguished from psoriasis, although this drug may precipitate attacks of psoriasis; it may be associated with fever and hyperleukocytosis Common 1% to 10% Rash, pruritus Uncommon 0.1% to 1% Pigmentary changes in skin and mucous membranes, bleaching of hair, alopecia Interface dermatitis found in the skin biopsy is a nonspecific inflammation at the dermis-epidermis junction that can be found in many connective tissue diseases, whereas eosinophil infiltrates suggested an allergic drug-induced exanthema. Hydroxychloroquine was the most likely culprit for her erythema multiforme. For all uses of hydroxychloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Hydroxychloroquine induced drug rash Hydroxychloroquine-Associated Hyperpigmentation Mimicking., Hydroxychloroquine Side Effects - Symptoms of eye problems from plaquenilDoes hydroxychloroquine cause discoloration of palms of handsChloroquine lysosome disruptionHydroxychloroquine skin lightening Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine Uses, Dosage & Side Effects -. Hydroxychloroquine-induced erythema multiforme. Risks of Hydroxychloroquine. Drug- and chemical-induced photosensitivity occurs when a drug or chemical agent combines with UV radiation to cause a phototoxic or photoallergic reaction. These agents are called photosensitisers and can be topical agents or medications that are taken orally. Hydroxychloroquine is used to treat rheumatoid arthritis; discoid and systemic lupus erythematosus SLE. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine is an antimalarial drug that is also used in the treatment of various rheumatic diseases including systemic lupus erythematous SLE. Various adverse reactions include skin rash, diarrhea, nausea and retinopathy were reported 1. Hydroxychloroquine induced myopathy is a rare side effect and reported prevalence is up to 6.7% 2.