Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Does plaquenil stop joint destruction in ra Plaquenil and quinicrine not working anymore for lupus Chloroquine patient information leaflet Chloroquine is a lysosomotropic agent that prevents endosomal acidification. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine cell effect Aralen chloroquine Malaria Drug Side Effects & Dosage, Chloroquine & Hydroxychloroquine supporting chemo. Plasmodium falciparum chloroquine resistance transporterIs plaquenil an antimalarial drugCan plaquenil cause gingivitis in humansDoes plaquenil cause you to gain weight The protective effect of chloroquine on stem cells and committed progenitors is potentially a groundbreaking feature of this compound, as it would be prescribed to women at childbearing age that are traveling to affected countries and women planning pregnancy in endemic areas. Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika.. Effects of chloroquine on viral infections an old drug.. Chloroquine in Cancer Therapy A Double-Edged Sword of.. Abstract. Chloroquine liberated a relatively low amount of histamine from isolated rat mast cells. In a dose-dependent way, this drug inhibited histamine liberation from mast cells stimulated with compound 48/80, A23187, concanavalin A plus phosphatidylserine Con A+PS and abolished histamine liberation induced by exaprolol. Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body. Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.