While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. The studies that do exist show mixed results (some show Nonetheless, despite the lack of clinical studies, rheumatologists feel that hydroxychloroquine may have a potential beneficial effect in helping patients with symptoms of fatigue and achiness, which are common complaints in patients with Sjögren’s. Hydroxychloroquine and ibuprofen together Plaquenil and estrogen A month ago I started on Plaquenil and prednisolone. It has helped a bit with the inflammation but on reading various items on the Internet, Plaquenil seems to be for joint pain and inflammation but skin is not mentioned. I seem to be able to keep that in check with my daily Pilates and if that is its main effect I would rather not take it. I've heard that plaquenil does help w/ fatigue as well as the pain? Is this true. Right now I am not on any Dmards but when I push myself more than like 4 hrs a day out of the house running errands, etc I totally crash w/ fatigue and pain. I take tramadol and NSAIDs but wondering if I need. How do antimalarial drugs work to control lupus symptoms? Here are some of the ways in which Plaquenil is used to control lupus symptoms May prevent lupus flares by as much as 50%; Reduce muscle and joint pain; Reduce lupus related rashes; Protect against pleuritis inflammation of the lining of the lungs The good news is that hydroxychloroquine targets the immune system without causing an increase in the risk of infection or cancer that can be seen with other immunosuppressant medications. How the drug works is unclear, but recent research has pointed to an inhibitory effect on toll-like receptors that are proteins involved with inflammation. Does plaquenil help with inflammation Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Plaquenil for fatigue and pain DailyStrength Plaquenil and tinnitusCan hydroxychloroquine be used for thyroidHydroxychloroquine pediatric dose Fatigue is the result of the inflammation. If Plaquenil hydroxychloroquine works, it will also help the fatigue. Plaquenil hydroxychloroquine helps inflammation, will.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Also called Plaquenil, hydroxychloroquine is a disease-modifying drug that can help decrease both the swelling and pain of rheumatoid arthritis. According to, there is not a clear reason why hydroxychloroquine is so effective in treating autoimmune diseases. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Osteoarthritis and for what kind of people. The study is created by eHealthMe from 10 Plaquenil users and is updated continuously. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA reports. I think it depends on the degree of one's RA disease as to how one feels on Plaquenil. So i would have to say for me that along with being on other Biologics such as Enbrel, Orencia, Simponi, Cimzia and now Rituxan and Arava another DMard, Plaquenil does help.