I was losing weight without trying before starting on the plaq - and seem to be gaining without changing much of anything - since then, other than increasing my activity. I also find that eating a lot of carbohydrates helps with the GI effects of the plaq and that can contribute to weight gain. Gonna have to bite the bullet and really get serious about dieting and see what happens. Almost any med that can cause weight loss can also cause weight gain. Plaquenil alternatives lupus Hydroxychloroquine pruritus Plaquenil can cause loss of appetite and I agree that losing weight at this rate and suffering diarrhea is not healthy and might mean you become ill nourished and dehydrated. I suggest lowering the dose, going back to the original, until your tum has settled down then very gradually increasing it to give your body the maximum chance to adjust. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. In this case, the cause of loss f appetite and weight loss has to be found. The only thing that I could figure was it was from the Plaquenil so I stopped taking it. I had not changed my eating habits or my exercise habits during those 2 yrs. Does plaquenil make you gain weight Common and Rare Side Effects for Plaquenil Oral, Plaquenil Side Effects Common, Severe, Long Term - Generic hydroxychloroquine genericHydroxychloroquine 200 mg good rx Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Plaquenil Uses, Dosage & Side Effects -. Plaquenil and loss of appetite - Lupus - MedHelp. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Since the side effect of vision loss is possible but rare, it is important for you to tell your doctor about any vision changes that you experience. Doctors generally recommend regular eye exams while on Plaquenil, so that early changes can be caught. Once abnormalities are discovered, toxicity has already occurred. I was on plaquenil for about a year. Didn't notice any weight gain. Sometimes it is hard to pin down what is causing things, though. Meds are funny. Even antihistamines can make you gain weight. Hope you are able to figure this out soon! Lynwood, I can't answer your question about weight gain or loss on plaquenil but I did go off plaquenil a few months ago and haven't been the same since. I regret the decision which had I made because I'd felt pretty well for quite some time and was doing my best to slowly get off as many meds as possible.