Those with APS make abnormal proteins called antiphospholipid autoantibodies in the blood. This causes blood to flow improperly and can lead to dangerous clotting in arteries and veins, problems for a developing fetus and pregnancy miscarriage. Plaquenil for sjogrens Chloroquine and sun exposure Fatigue plaquenil To receive a diagnosis of APS, patients must test serologically positive for at least one of the following on two occasions 12 weeks apart anticardiolipin antibodies, anti-beta-2-GPI antibodies aB2GPI and/or lupus anticoagulant. Of these, B2GPI may be the most relevant target of the antiphospholipid antibodies. Approved for lupus by the Food and Drug Administration FDA in the 1950s, recent research suggests that Plaquenil may help lower the risk of a blood clot in people who have lupus and antiphospholipid antibodies. Plaquenil is “such a simple drug, and yet so powerful,” says Askanase. “It is the aspirin for lupus.” Antiphospholipid syndrome APS, an autoimmune systemic disease characterized by circulating antiphospholipid antibodies aPL, places women at risk of adverse pregnancy outcomes, such as recurrent pregnancy loss and late gestational complications including preeclampsia and associated premature delivery, HELLP syndrome hemolytic anemia, APS affects women five times more commonly than men. People with this disorder may otherwise be healthy, or they also may suffer from an underlying disease, most frequently systemic lupus erythematosus (commonly called lupus or SLE). Plaquenil preeclempsis antiphospholipid Antiphospholipid antibody syndrome Lupus Foundation of America, Antiphospholipid Syndrome Evaluating current treatment. Available doses of hydroxychloroquinePlaquenil antiplatelet400mg plaquenil at nightAnti malaria pills chloroquine Patients with antiphospholipid syndrome APS also present with endothelial dysfunction, which can become thrombosis and early atheroma. Prior research has proposed the decreased dilation in APS patients may be the result of reduced nitric oxide bioavailability. The preservation of endothelial nitric oxide function requires, among other things, the bioavailability of tetrahydrobiopterin. Is Hydroxychloroquine Helpful for Patients with.. Hydroxychloroquine Prevents Antiphospholipid Antibody.. Antiphospholipid antibody syndrome Lupus Foundation of.. This summary, the second segment of this two-part presentation, focuses on antiphospholipid syndrome. For more information on lupus, please read Recent Developments in Managing and Treating Lupus and Antiphospholipid Syndrome APS Part I – Lupus. Antiphospholipid antibodies are a group of immune proteins that the body mistakenly produces against itself in an autoimmune response to phospholipids. Tests can detect these autoantibodies that bind to phospholipids and, in a way that is not well understood, increase the risk of excessive blood clotting. What is antiphospholipid syndrome? Antiphospholipid syndrome APS is a systemic autoimmune disease characterized by production of antibodies – antiphospholipid antibodies aPL – that “attack” the person’s own body, resulting in blood clots and/or pregnancy complications. Antiphospholipid-antibody-positive patients also may develop other clinical problems.