This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. For prevention of malaria in adults, one dose is usually taken once a week on exactly the same day of the week. Imuran plaquenil together Hydroxychloroquine test for eyes Summary. Aralen is the brand name for the generic drug chloroquine, an anti-malaria drug used to treat malaria and amebiasis infection that's spread outside of the intestines. Dosage, drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this drug. Clinical trials are in progress testing chloroquine CQ or its derivatives in combination with chemo- or radiotherapy for solid and haematological cancers. Chloroquine CQ was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance. Recent reports have suggested that CQ-susceptibility may return following the cessation of CQ usage. One dose is taken beginning 2 weeks before traveling to an area where malaria is common, while you are in the area, and then for 8 weeks after you return from the area. Your doctor will tell you how many tablets to take for each dose. Chloroquine resistance testing Chloroquine - FDA prescribing information, side effects and uses, Lysosomotropism depends on glucose a chloroquine resistance. Hydroxychloroquine brand nameChloroquine hemolytic transfusionPlaquenil mefloquine Chloroquine became the drug of first choice in malaria therapy for more than two decades until resistance limited the use of the drug. The resistance is correlated to point mutations in the gene pfcrt 26. The gene codes for a transporter PfCRT. Chloroquine - an overview ScienceDirect Topics. Return of chloroquine sensitivity to Africa? Surveillance of.. Drug Resistance in the Malaria-Endemic World - CDC. A standardized in vivo test protocol for assessing the response of P. falciparum to chloroquine was first developed in 1965 and after many revisions, the latest protocol has been put forth by the WHO in 2003.22 It involves a fairly simple, prospective evaluation of the clinical and parasitological response to treatment for uncomplicated malaria. In regions of high resistance where chloroquine has been replaced by other drugs, periodic PfCRT K76T surveys may detect declining rates of resistance, permitting consideration of reintroducing chloroquine, perhaps in combination with chemosensitizing agents or other antimalarial drugs Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.