Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine in sle Chloroquine free base If you are also taking a certain drug for diarrhea kaolin or taking antacids such as magnesium/aluminum hydroxide, take hydroxychloroquine at least 4 hours before or after these products. I’ve been on plaquenil for almost 3 years and I still have diarrhea and to a lesser extent heartburn and nausea sometimes. The first year or two I was on plaquenil I didn’t have a normal bowel movement for as long as I could remember and was constantly nauseous and could barely eat. Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil hydroxychloroquine. If you have heart, eye, liver conditions, or psoriasis, talk to your doctor to see if Plaquenil hydroxychloroquine is right for you. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil for diarrhea Hydroxychloroquine Plaquenil, Plaquenil and. diarrhea! rheumatoid Is plaquenil a immunosuppressantAllergy to chloroquine which anti-malaria tablets should you take I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. I understand these may go away. Is there anything I can. Stomach problems with Plaquenil • Johns Hopkins Arthritis Center. Compare Plaquenil vs Chloroquine -. PATIENT FACT SHEET Hydroxychloroquine Plaquenil. I had severe nausea and diarrhea when started on Plaquenil 2 X 200mg tabs once daily almost 3yrs ago. As I also have Crohn's Disease and an Ileostomy this was putting me at serious risk. I was told to stop the Plaquenil until my GI symptoms disappeared. Diarrhea difficulty breathing difficulty seeing at night dizziness or fainting fast, pounding, uneven heartbeat feeling that others are watching you or controlling your behavior feeling that others can hear your thoughts feeling, seeing, or hearing things that are not there fever with or without chills Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation.