Its been nearly seven years since my I first started getting hives. It started out of the blue and it didn't start small. So this would explain why I have awful hives everywhere. Plaquenil hydrochloroquine Plaquenil changed your hair Hydroxychloroquine patient Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. The response to prednisone and rapidity of response suggests that the swelling is histamine dependent. I suspect that the angioedema is unrelated to the tingling of the tongue or the hydroxychloroquine. Since the disease being treated successfully is serious, I do not feel you must discontinue the hydroxychloroquine. My lips would swell to the size of sausages and my eyes would swell shut. (except for the steriods, which I can't stay on for a more than a few weeks.) I was given epipens in case of an emergency and sent home to wallow in pain. I went to a new allergist just today and he finally gave me an answer for what could be causing my hives. But I'm only just getting to best part (no sarcasm intended). I was rendered unable to walk most times because the hives swell over my ankles and knees making them painfully impossible to move. My arms, legs, feet, back, hands, belly, and chest. I may be taking nearly six a day, but they are working. Hashimoto's thyroiditis is an autoimmune disease in which the thyroid gland is attacked by a variety of cell- and antibody-mediated immune processes. So now I have to go in for more testing (yay :[ ) to see if I have said disease. Hydroxychloroquine urticaria angioedema Urticaria - American Osteopathic College of Dermatology AOCD, Hydroxychloroquine - Wikipedia Is hydroxychloroquine safe while pregnantChloroquine diabetesHydroxychloroquine side effects weight lossPlaquenil pregnancy safety Chronic urticaria is defined as hives, typically occurring daily, for greater than 6 weeks duration. The associations between chronic urticaria, thyroid disease, and other autoimmune disorders, as well as the implications that this holds for therapeutic intervention are reviewed. Chronic Urticaria Hives and Autoimmunity. Hydroxychloroquine and angioedema AAAAI. Hydroxychloroquine Efficacy in Chronic Urticaria - Full Text.. Urticaria is a skin condition characterized by erythematous, blanching, edematous, nonpainful, pruritic lesions that typically resolve within 24 hours and leave no residual markings. Angioedema is swelling involving the deeper layers of the subdermis and occurs in association with urticaria in ab. Summary Angioedema is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Xolair, and have Cardiac failure. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food. Sep 04, 2018 Limited small studies of anti-inflammatory agents have shown dapsone, sulfasalazine, hydroxychloroquine, and colchicine to provide clinical benefit in patients with chronic urticaria or angioedema. This group of medications is associated with higher risk than antihistamines or H2 antagonists and leukotriene receptor antagonists.